Adrenergic Modulation with Photochromic Ligands
semanticscholar(2020)
Abstract
Adrenoceptors are ubiquitous
and regulate heart and respiratory
rate, digestion, metabolism, and vascular tone. They can be activated or
blocked with adrenergic drugs, but systemic administration causes broad adverse
effects. We have developed photochromic ligands (adrenoswitches) to switch on
and off adrenoceptor activity on demand at selected locations. Their pharmacology,
photochromism, bioavailability and lack of toxicity allow photomodulating adrenergic
signalling, as demonstrated by controlling locomotion in zebrafish and pupillary
responses in blind mice.
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