A Correlative Study of Hemodynamically Significant Patent Ductus Arteriosus and Platelets within 24 hours of Birth in Preterm Infants

Objective To investigate the correlation between the hemodynamically significant patent ductus arteriosus (hsPDA) of preterm infants and the platelet count (PLT), plateletocrit within 24 h of birth.Methods The clinical data of 1270 preterm infants were retrospectively studied. The patients were divided into the non-PDA group, no hsPDA group, and hsPDA group.Results The smaller gestational age and the lower birth weight, PLT, plateletocrit were associated with the greater likelihood of PDA ( P < 0.05). The receiver operating characteristic (ROC) curve showed that the predictive values of PLT and plateletocrit were 0.703 and 0.748, respectively, with the best critical values of 241.5 × 10 9 /L and 0.245%. For the preterm infants with PLT < 241.5 × 10 9 /L, < 150 × 10 9 /L and < 100 × 10 9 /L as well as plateletocrit < 0.245% and 0.09%, the risks of hsPDA were 1.876, 2.169, 6.216, 1.749 and 5.407 times of preterm infants with PLT ≥ 241.5 × 10 9 /L, ≥ 150 × 10 9 /L and ≥ 100 × 10 9 /L as well as plateletocrit ≥ 0.245% and ≥0.09%. The logistic regression analysis showed that plateletocrit was an independent risk factor for preterm infants with hsPDA ( P = 0.000).Conclusions The decrease in plateletocrit of the preterm infants within 24 h of birth was the independent risk factor of hsPDA on the 4th-7th day of birth.