Correlations of serum TNF-α, IL-1β and IL-1 with the pain degree in patients with instability in traumatic anterior shoulder joints

Objective: The objective of this study was to observe the expression levels of serum interleukin-1 (IL-1), IL-1β and tumor necrosis factor-alpha (TNF-α) in patients with instability in traumatic anterior shoulder points, and to study their correlations with the pain degree. Methods: In our hospital, a total of 40 patients with instability in traumatic anterior shoulder points who were hospitalized, scheduled to receive shoulder joint arthroscopic surgery, and met the inclusion criteria between January 2017 and October 2017 were selected in this study. After admission, the relevant examinations were completed, the venous blood was collected, and the VAS score was used to evaluate the pain degree. Correlation analyses were conducted to study the correlations of the levels of serum IL-1, IL-1β and TNF-α before treatment with VAS scores. Results: Compared with those before treatment, the levels of serum IL-1, IL1β and TNF-α expression after treatment were significantly decreased (P<0.05). Compared with those before treatment, the levels of serum IL-1, IL-1β and TNF-α mRNA expression were significantly decreased (P<0.05). Compared with that before treatment, the VAS score was significantly decreased after treatment (P<0.05). Additionally, the VAS score was gradually decreased with the extension of time (P<0.05). The variation trend of the expression levels of inflammatory cytokines before and after treatment was consistent with that of the VAS score. The serum IL-1, IL-1β and TNF-α levels were positively correlated with the VAS score. Conclusion: Inflammatory response occurs in serum of patients with instability in traumatic anterior shoulder joints. The expression levels of IL-1, IL-1β and TNF-α are positively correlated with the pain degree of shoulder joint.