Optimized Synthesis Method for Magnetic Nanoparticles Corporate with Radioactive Copper

The single-particle combine with both radioactive and magnetic properties can use PET-MRI contrast agents. This technique has been attracting attention as a nextgeneration nuclear medicine for the diagnostic device. Generally, the research and development of PET-MRI contrast agents have focused on the synthesis of chemical labeling compounds, which have developed from synthesizing technology of nuclear medicine contrast agents by ligand binding between magnetic superparamagnetic iron oxide (SPIO) and radioactive labeling compounds.[1,2,3] But, recently the development of a nanoparticle synthesis method with two different elements into a single-particle can be applied to bi-functional nanoparticle manufacturing technology, which makes different single heteronuclear elements with radioactive and magnetic properties into a single particle. This type of new contrast agent technology is an excellent research area to have the leading role of technology development in nuclear medicine imaging for contrast agent market and securing the source technology through future R&D. This present study is devoted to the synthesis of singlecore nanoparticles combining heterogeneous elements by a cold model method using stable isotope material for optimized synthesis method. In this, The main conditions of the synthesis method are similar to those of the previous paper, and experiments were conducted to optimize the synthesis method and to construct a dedicated synthesis reactor to scale up the RMNP by more than five times.[4] In this study, the Fe element used as a magnetic component for MRI (Magnetic Resonance Imaging) imaging, and the stable isotope Cu ion used as the model for Cu, Cu radioisotope for PET (Positron Emission Tomography) imaging. The nanoparticles synthesized via hydrothermal reaction performed under 200 ° C with a mechanical mixer at 200 rpm. Then the recovered hydrophobic nanoparticles surface was converted to the hydrophilic surface using tetraethoxysilane coating agent. The size of the recovered RMNP confirmed to optimized to 6nm.