Leishmania donovani infection induce Extracellular signal-regulated kinase ½ (ERK½) mediated lipid droplet generation in macrophages

Somenath Banerjee,Dipayan Bose,Subhadip Das,Nabanita Chatterjee,Snehasish Mishra,Krishna Das Saha

Molecular Immunology（2022）

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摘要

•L. donovani ag83 induce LD generation in macrophages.•ERK1/2 is responsible for LD generation.•Neutralization of LD generation restores phago-lysosome biogenesis.•Diminishing LD generation also correlated with augmentation of IL-12.

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LPG,Mϕ,LD,BAF,ASP

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