Evaluation of hepatoprotective activity of tectona grandis linn

Hepatic damage is associated with distortation of t he metabolic functions of liver. Thus liver diseases remain as the serious health problems. The present study was aimed to evaluate the hepatoprotective activity of hydroalcoholic extract of Tectona grandis leaf. The phytochemical screening showed the presence of alkaloids, amino a cids, carbohydrates, flavonoids, saponins, steroids, triterpenoids, and tannins. Evaluation of hepatoprotective activity of hydroalcoholic extrac of Tectona grandis leaf was carried out at two dose levels 300 mg/Kg and 600 mg/Kg. Carbon tetra chloride induced hepatotoxic model was followed for investigation of hepatoprotective activity of Tectona grandis in wistar rats. The biochemical parameters (SGOT, SGPT and ALP) in rat serum were found to be increased in CCl 4 induced hepatotoxicity model. Hydroalcoholic extrac of Tectona grandis leaf was found to decrease the biochemical paramet ers (SGOT, SGPT and ALP) of rat serum at the doses of 300 mg/Kg and 600mg/Kg. Hydro alcoholic extract of Tectona grandis leaf significantly (p≤0.05) and dose dependently produced hepatoprotectiv e activity at the doses of 300 mg/Kg and 600 mg/Kg.