Phase I trial of the PI3Kα isoform inhibitor TAK-117

Massachusetts General Hospital, Boston, MA. The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom. Yale University, New Haven, CT. Mary Crowley Cancer Research Center, Dallas, TX. Karmanos Cancer Institute, Wayne State University, Detroit, MI. Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain. Investigative Clinical Oncology, Fondazione Del Piemonte Per L'Oncologia, Candiolo Cancer Institute, Candiolo, Italy. Millennium Pharmaceuticals, Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited. *Current affiliation: Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.