Structures of HIV-1 reverse transcriptase with HBV-associated triple mutations in complex with chirally-distinct nucleoside analogues, ETV-TP and 3TC-TP

Yoshiaki YASUTAKE1,2,*, Shin-ichiro HATTORI3, Noriko TAMURA1, Kouki MATSUDA3, Satoru KOHGO3,4, Kenji MAEDA3, Hiroaki MITSUYA3,5,6 1Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo 062-8517, Japan 2Computational Bio Big-Data Open Innovation Laboratory, AIST, Tokyo 169-8555, Japan 3National Center for Global Health and Medicine (NCGM) Research Institute, Tokyo 162-8655, Japan 4Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan. 5National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA. 6Kumamoto University Hospital, Kumamoto 860-8556, Japan.