Autologous Free Fascia Lata Can Be Used as Dura Graft in the Salvage Treatment of Recalcitrant Postcraniotomy Intracranial Infection Caused by Multidrug-Resistant Gram-Negative Bacteria

Objective: The multidrug-resistant (MDR) gram-negative bacteria-induced intracranial infections after neurosurgical procedures represent a particular therapeutic challenge. Combining the removal of infected prosthetic meninge plus an appropriate antibiotic administration appears to be the only therapeutic strategy likely to succeed when the infection is complicated by artificial dura mater. This study aimed to assess the efficacy of free fascia lata as a substitute for dura reconstruction in the salvage treatment for such recalcitrant nosocomial infections. Methods: The retrospective, observational study was conducted at Shanghai Tenth hospital. Patients with definite intracranial infection caused by MDR Gram-Negative bacteria who underwent salvage dura reconstruction using autologous free fascia lata were included in the study. Electronic medical data on clinical characteristics, underlying condition, bacterial culture, antibiotic susceptibilities, perioperative management, surgical techniques, outcome, and follow-up were collected and analyzed. Results: 19 patients were included in the study cohort. All these patients underwent salvage surgery, including removal of infected artificial dura substitute, achievement of complete dura seal with free fascia lata, and other adjunctive procedures to drain the CSF and infuse sensitive antimicrobial agents. Intraventricular or intrathecal administration of antibiotics, including Colistin (14 case), Tigecycline (1 case), Amikacin (1 case), was employed in 16 patients. The infection was cured in 17 patients. In-hospital death occurred in 3 patients. One died from multiple system/organ failure, 1 died from massive occipital ICH, 1 died from brain stem hemorrhage after ventricular-peritoneal shunt surgery. The patients remained without clinical evidence of recurrence during the follow-up period. Conclusion: On the basis of a comprehensive approach to achieving prompt sterilization of causative pathogens and an optimal healing environment, free fascia lata can serve as a simpler but effective option for dura reconstruction even in the setting of a severe septic area for patients who otherwise need much more complicated and demanding tissue transfer surgery.