Running title: MET exon 14 Mutation in Lung Adenocarcinoma Key words: Targeted therapy, Non-small cell lung cancer, acquired resistance Abbreviations list: MET: mesenchymal-epithelial transition HGF: Hepatocyte growth factor Financial support: M. Meyerson is supported by an American Cancer Society R

Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center University of California, San Francisco, CA 94143, USA. 2 Thoracic Cancer Unit, Davidoff Cancer Center and Tel Aviv University, Petach Tiqwa, 49100, Israel Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA Department of Pathology, University of California, San Francisco, CA 94143, USA, Current Address: Department of Pathology, University of California, Davis 95616, USA Department of Biomedical Engineering, University of California, Santa Cruz, CA 95064, USA