Bacteroides, butyric acid and t10,c12-CLA Changes in Colorectal Adenomatous Polyps

semanticscholar(2020)

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摘要
Background Colorectal adenomatous polyps (CAPs) are considered precancerous lesions of colorectal cancer (CRC). There are few studies on patients with CAPs, and studies on microbial communities in the intestinal tract of CAP patients are inconsistent. The gut microbiota participates in the process of digestion and, in the process, produces metabolites, mainly short-chain fatty acids (SCFAs), secondary bile acids and conjugated linoleic acid (CLA). These studies aimed to investigate the gut microbiota and metabolites in the faeces of CAP patients in order to identify microbiota or metabolites that can be used as sensitive biological predictors and to provide a theoretical basis for the clinical treatment of CAPs. Results faecesWeissella and Lactobacillus were present in the HC group, and the abundance of Bacteroides and Citrobacter was higher in the CAP group than in the HC group. The expression of butyrate-producing bacterial genes was significantly higher in the faeces of CAP patients, but that of secondary bile acid-producing bacterial genes and CLA-producing bacterial genes showed no differences in either faeces or biopsy tissues, and that of butyrate-producing bacterial genes showed no differences in biopsy tissues. The contents of acetic acid and butyric acid were increased in the faeces of the CAP group, and the HC group had higher contents of t10,c12-CLA. Conclusion The results of gut microbiota in faeces showed no specific correlation between CAP patients and healthy individuals, but there was indicate that changes of specific genus might be detrimental to intestinal health. In addition, t10,c12-CLA played an important role in protecting the intestine.
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