Ablated intestinal stem cells recover predominantly by ASCL2-dependent dedifferentiation of their recent progeny

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA Departments of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, 3584 CT Utrecht, the Netherlands Department of Cancer Data Sciences, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138 Department of Cancer Immunology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA