Vplyv katetrizačnej renálnej denervácie sympatiku na renálne funkcie a na renálne tepny

Objective: Currently investigated non-pharmacological minimally invasive method for the treatment of resistant hypertension is percutaneous denervation of renal sympathetic nerve fi bres by radiofrequency catheter-based ablation. We assessed its infl uence on renal function and renal arteries. Methods: The fi rst 38 patients treated with catheter-based renal denervation at our centre between September 2011 and December 2012 were included in the study. Changes in renal function and changes in renal artery morphology at 12 months after the procedure have been analyzed. Results: Mean age was 57.6 ± 11 years, the majority (63.9%) were men. Average estimated glomerular fi ltration rates (eGF) were 1.25 ml/s/1.73 m before denervation and 1.30 ml/s/1.73 m 12 months after intervention. Changes in eGF did not reach statistical signifi cance. New haemodynamically non-signifi cant renal artery stenosis (40%) has occurred in only one case after procedure. Conclusion: In agreement with the results of several studies, our fi ndings suggest that renal denervation (RDN) appears to be a safe therapeutic approach. Kľúčové slová: Renálna denervácia Renálne funkcie Renálne tepny Rezistentná hypertenzia Tento článek prosím citujte takto: J. Kypusová, et al., The influence of catheter-based renal sympathetic denervation on renal function and renal arteries, Cor et Vasa 57 (2015) e245–e250, jak vyšel v online verzi Cor et Vasa na http://www.sciencedirect.com/science/article/pii/S001086501500065X#