Molecular study of helicobacter pylori for patients with coronary heart disease

Coronary heart disease (CHD) or Ischemic heart disease (IHD) which is the product of atherosclerotic plaques accumulating within the walls of the arteries supplying the heart muscle; A recent study reported the presence of Helicobacter pylori deoxyribonucleic acid (DNA) in atherosclerotic plaques in patients with acute coronary syndrome, bolstering the theory that H. pylori infection influences atherosclerosis growth. The aim of the study was to use conventional PCR to detect the presence of the16SrRNA gene, cytotoxinassociated gene A (cagA), and the vacuolating cytotoxin gene A (vacA) products which considered the most important pathogenic determinants of H. pylori for 98 tissue sample from Al-Diwaniyah, Teaching Hospital and medical city of Al-Emam Al-Hussain, (50) patient with CHD and (48) tissue gastric samples from people without (CHD). our results showed that (28.5% ) with CHD and (71.42%) without CHD was positive for 16SrRNA gene of H.pylori. while for cagA gene (17.4% , 42.85%) with and without CHD, respectively and for gene A (vacA) (14.28% 48.57%) with and without CHD, respectively. All result was statistically significant.