Microbiome insights into the perforated duodenal ulcer via metagenomic sequencing

Background Perforated duodenal ulcer is a common condition. The associated microbiome and relationship with treatment success remain to be explored in addition to the well recognized role of Helicobacter pylori.Methods Metagenomic sequencing were used to profile the microbes underlying duodenal ulcer. The metagenome results of 6 duodenal ulcer samples (3 ulcer foci and 3 sites around the ulcer foci) were obtained and compared.Findings Ulcer patients and healthy control have different gut-type. Streptococcus mitis was highly enriched in duodenal ulcer patients.Interpretation The dysbiosis of microbiomes might underlie the duodenal ulcer, while the increased abundance of Streptococcus mitis is a novel finding. Whether there is causal link between S.mitis and duodenal ulcer remains to be determined.