A sticky bacterium versus antiadhesive surfaces: The adhesion preference of bacteria expressing trimeric autotransporter adhesin
semanticscholar(2020)
摘要
The COVID-19 pandemic caused by a virus
has been posing a global threat to humanity and human society. It reminded us
of the horror of infectious diseases. Pathogenic bacteria also cause infectious
disease, but bacteria are not as much of a threat as viruses because
antibiotics are effective against them. This is changing, however, with the
emergence of antibiotic-resistant bacteria. The global expansion of multidrug-resistant bacteria has become a
clinical problem, and the threat of bacterial infection would come back in the
near future. The overuse of antibiotics amplifies the opportunity for resistant bacteria to emerge and spread. The
increased antibiotic use during this
COVID-19 pandemic could also increase the threat of resistant bacteria. As
an alternative to antibiotics, antibiofouling surfaces have drawn intensive
research interest and have been developed. Acinetobacter sp. Tol 5
exhibits high adhesiveness to various surfaces through AtaA, a member of the
trimeric autotransporter adhesin (TAA) family. We examined the adhesion of Tol
5 and other bacteria expressing different TAAs to antiadhesive surfaces. The
results highlighted Tol 5’s stickiness through AtaA, which enables cells to
adhere even to antiadhesive materials including polytetrafluoroethylene with a
low surface free energy, a hydrophilic polymer brush exerting steric hindrance,
and mica with an ultrasmooth surface. Tol 5 cells also adhered to a
zwitterionic 2-methacryloyloxyethyl-phosphorylcholine-polymer-coated surface
but were exfoliated by a weak shear stress, suggesting that exchangeable bound
water molecules contribute to AtaA’s interaction with materials.
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