Klein Fetuses with Posterior Urethral Valves ( PUV ) Fetal Urinary Peptides to Predict Postnatal Outcome of Renal Disease in

families make prenatal treatment decisions for fetuses with PUV. needed for validation, this peptide-based predictor shows promise as a much needed test to help clinicians and routine clinical procedures such as ultrasound and biochemical tests. Although many more fetal urine samples are this peptide-based signature, called 12PUV, was similarly able to predict postnatal renal function, outperforming but were not present in the fetal urine of patients who did not progress to ESRD. In an independent set of samples, identified a handful that were linked to ESRD, et al. they had ESRD before the age of 2. Out of >4000 peptides, Klein of the urinary tract that can lead to ESRD. They knew the outcome of these patients with PUV, that is, whether or not The authors obtained urine samples from fetuses with posterior urethral valves (PUV), which is an abnormality in fetal urine to find potential markers of end-stage renal disease (ESRD). peptides make informed treatment decisions earlier. To this end, Klein and colleagues searched through thousands of whether a fetus will have severe kidney disease would help anxious parents −− in utero −− Being able to predict Seeking a Signature of Renal Disease