P87 structural brain correlates of cognitive and behavioural impairment in mnd

Methods: 101 patients with sporadic MND and 51 controls were enrolled in this study. Patients were classified into MND with a pure motor syndrome (MND-motor) and with cognitive/behavioural symptoms (MND-plus) based on a comprehensive neuropsychological evaluation. Cortical thickness measures and diffusion tensor (DT) metrics of white matter (WM) tracts were assessed. A random forest approach was used to explore the independent role of cortical and WM abnormalities in explaining major cognitive and behavioral symptoms.