Noninvasive, label-free optical method visualizes deep, cellular brain disease in vivo

a, Minimum intensity projection sagittal images, or "slices", with different projection thicknesses in the coronal direction, show cortical cytoarchitecture and the corpus callosum (CC), without physical tissue slicing. b, OCM signal decay (left panel) and averaged coronal image (middle panel) show sub-cortical layers. CC: corpus callosum; Or: stratum oriens; Rad: stratum radiatum; DG: dentate gyrus. Credit: Jun Zhu, Hercules Rezende Freitas, Izumi Maezawa, Lee-way Jin, and Vivek J. Srinivasan