Single-cell RNA-seq Imputation using Generative Adversarial 1 Networks 2

Yungang Xu, Zhigang Zhang, Lei You, Jiajia Liu, Zhiwei Fan, Xiaobo Zhou 3 1 Center for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas 4 Health Science Center at Houston, TX 77030, USA 5 2 School of Information Management and Statistics, Hubei University of Economics, Wuhan, Hubei 6 430205, China 7 3 Department of Pediatric Surgery, McGovern Medical School, The University of Texas Health Science 8 Center at Houston, Houston, TX 77030, USA 9 4 School of Electronics and Information, Tongji University, Shanghai, Shanghai 201804, China 10 5 West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 11 Chengdu 610040, China 12 6 Hubei Center for Data and Analysis, Hubei University of Economics, Wuhan, Hubei, 430205, China 13 14 These authors contributed equally to this work. 15 Correspondence: xiaobo.zhou@uth.tmc.edu 16