Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions

Ross Cheloha, Fabian A. Fischer,Andrew W. Woodham, Eileen Daley,Naomi Suminski, Thomas J. Gardella,Hidde L. Ploegh

semanticscholar（2019）

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摘要

Here we describe a new method for improving signalling potency and selectivity for suboptimal GPCR ligands through conjugation with receptor-targeting nanobodies

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