Cerebral Venous Sinus Thrombosis (CVST): An Emerging Com- plication of SARS CoV-2 Infection

BACKGROUND Cerebral venous sinus thrombosis (CVST) is an uncommon cause of stroke (<1%) (Nwajei F, et al., 2020), with an annual incidence of 2-5 cases per million people, more commonly occurring in younger patients, particularly women. Most common symptoms are headache, seizures and focal neurologic deficits, while several risk factors, like an inherited coagulopathy, an antecedent history of trauma, cancer, or use of hormonal contraceptives have been identified (Dakay K, et al., 2020). During last year, it has been assumed that SARS-CoV-2 may represent a new risk factor for CVST, by binding with angiotensin converting enzyme 2 (ACE2) receptors and triggering a cytokine cascade which leads to a hypercoagulable state (Nwajei F, et al., 2020). Although venous thromboembolic events in other anatomic districts have been widely described in literature, CVST still represents a less frequently reported condition.