Formulation and In-Vitro Evaluation of Valsartan Fast Dissolving Tablets by Direct Compression Technique
semanticscholar(2019)
Abstract
Valsartan is an angiotensin II receptor antagonist and is widely used in the management of hypertension to reduce cardiovascular mortality in patients with left ventricular dysfunction following myocardial infarction, and in the management of heart failure. Valsartan fast dissolving tablets have been prepared by direct compression technique. Effect of superdisintegrant croscarmellose sodium (CCS) on disintegration time, wetting time, Water absorption ratio, drug content in-vitro release and stability parameters have been studied. Increase in the level of croscarmellose sodium the disintegration time and dissolution parameters (t50% and t90%) decreased. The stability study carried out as per ICH guidelines, the disintegration time of tablets decreased significantly (p<0.05). It is concluded that fast dissolving tablets of Valsartan could be prepared by direct compression technique.
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