Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia [version 1; peer review: awaiting peer review]

Vilas Navapurkar,Josefin Bartholdson Scott,Mailis Maes,Thomas P Hellyer,Ellen Higginson,Sally Forrest,Joana Pereira-Dias,Surendra Parmar,Emma Heasman-Hunt, Petra Polgarova,Joanne Brown, Lissamma Titti, William PW Smith,Jonathan Scott,Anthony Rostron,Matthew Routledge, David Sapsford,M. Estée Török,Ronan McMullan,David A Enoch,Vanessa Wong,Martin D Curran,Nicholas M Brown,A John Simpson,Jurgen Herre,Gordon Dougan,Andrew Conway Morris

semanticscholar（2021）

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摘要

Background: The diagnosis of pneumonia has been hampered by a reliance on bacterial cultures which take several days to return a result, and are frequently negative. In critically ill patients this leads to the use of empiric, broad-spectrum antimicrobials and compromises good antimicrobial stewardship. The objective of this study was to establish the performance of a syndromic molecular diagnostic approach, using a custom TaqMan array card (TAC) covering 52 respiratory pathogens, and assess its impact on antimicrobial Open Peer Review Reviewer Status AWAITING PEER REVIEW Any reports and responses or comments on the article can be found at the end of the article. Page 1 of 21 Wellcome Open Research 2021, 6:256 Last updated: 11 OCT 2021

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