Adrenergic Modulation With Photochromic Ligands

Davia Prischich,Alexandre M. J. Gomila,Santiago Milla‐Navarro,Gemma Sangüesa,Rebeca Diez‐Alarcia,Beatrice Preda,Carlo Matera,Montserrat Batlle,Laura Ramírez,Ernest Giralt,Jordi Hernando,Eduard Guasch,J. Javier Meana,Pedro Villa,Pau Gorostiza

Angewandte Chemie（2020）

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摘要

Adrenoswitches, a class of novel azoheteroaryl photoswitches, were developed to achieve on-demand modulation of adrenergic neurotransmission by means of illumination at specific wavelenghts. Their versatility to photocontrol biological systems is demonstrated in vivo employing two different animal models, zebrafish and mice.

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photochromic ligands

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