Aloe Vera Mediated Emulgel for Topical Delivery of Desoximetasone

Background: Desoximetasone (DMS), is a recommended drug against plaque psoriasis for topical cure. However, low water solubility and short half-life present the major obstacles in development of effective topical formulation. This demand for the development of effective topical system to deliver the hydrophobic DMS. Objective: The present investigation aimed at developing the aloe vera based emulgel formulation was to enhanced skin deposition of DMS to effectively treat plaque psoriasis. Methods: The different batches (DE1-DE4) of aloe vera emulgel was prepared using dispersion technique using varying concentration of propylene glycol (6 to 14 % w/w) and carbopol 934 (0.5 to 1.0% w/w). Result:The globule size evaluated by zetasizer was found in the range of 10.34 0.9 to 14.60 1.4 (n=50). Extrudability analysis revealed 5.6 0.11g/cm2 and 5.8 0.13 g/cm2 extrudability with DE3 and DE2 formulations. . The pH were found in the range of 5.8 to 6.8 and formulation DE3 showed maximum drug content 94.64 0.29 (n=3) as compared to other formulations and therefore used further in in vitro evalution. The optimized DE3 formulation was found to be firmer and with optimal spreadability (‘firmness’ 833.37 g mean max. force and ‘work of shear’ 324.230 g.sec. mean area) as compared to formulation DE2 as analysed using texture analyzer. Formulation DE3 exhibited 95.40±1.6 %DMS permeation within 7 h as detrmined using in house fabricated franze diffusion cell. The release mechanism of DMS was found to fit in korsmeyer Peppas model as revealed in in-vitro release kinetic investigation. nc orr cte d p roo f Conclusion: The physicochemical characterizations and enhanced in vitro permeation of DMS suggest that aloe vera emulgel could be efficiently employed for the topical treatment of skin ailments.