Resveratrol inhibits the P38MAPK pathway as well as downstream apoptosis, inflammation and oxidative stress molecule expression in secondary lung injury in intestinal ischemia-reperfusion

Intestinal ischemia-reperfusion injury can not only directly damage the intestinal mucosa barrier function and cause flora disorder, but can also cause the remote organ damage through the activation of systemic inflammatory response and oxidative stress reaction, and severe cases may lead to the occurrence of multiple organ dysfunction[1,2]. Acute lung damage is the common remote organ damage during intestinal ischemia reperfusion, and can cause acute respiratory distress syndrome and be life-threatening[3]. P38MAPK is the key signaling pathway regulating apoptosis, inflammation and oxidative stress in the body, the activation of the pathway is closely related to organ ischemia-reperfusion injury, and inhibiting P38MAPK activation is the key to treating intestinal ischemiareperfusion injury and remote viscera damage[4]. Resveratrol is a kind of nonflavanoids polyphenol extracted from grape and peanut roots, which has regulating effect on cell apoptosis, oxidative stress, endoplasmic reticulum stress, inflammation and other pathological processes, and has been proven to have protective effect on neuronal, myocardial and vascular endothelial ischemia-reperfusion injury[5]. At present, it is not yet clear about the resveratrol value for treatment of secondary lung injury in the intestinal ischemia reperfusion injury. In the following studies, the protective effect of resveratrol on secondary lung injury in intestinal ischemia reperfusion and its effect on P38MAPK pathway were analyzed.