Alcoholic liver disease
Medical review(2020)
摘要
Introduction. Alcoholic liver disease is one of the most common liver
disorders in Europe and in the United States of America. This paper
highlights the clinical-pathological concept of alcoholic liver disease with
an overview of current therapeutic approaches. The spectrum of alcoholic
liver disorders includes liver steatosis, alcoholic steatohepatitis,
alcoholic cirrhosis with a potential to culimate in hepatocellular carcinoma.
Alcoholic steatohepatitis is a rapidly-progressive disorder that may be
associated with severe clinical manifestations of alcoholic hepatitis and
high mortality. There are large variations in alcohol consumption and
consequent morbidity and mortality around the world. In addition to the
amount of alcohol intake, different individual manifestations of alcoholic
liver disease are affected by genetic and other risk factors. Pathogenesis
with a potential to culminate in hepatocellular carcinoma of the disease is
based on the toxic effects of acetaldehyde, oxidative stress, lipid
metabolism disorders and alcohol-induced inflammation. Diagnosis of alcoholic
liver disease. In the diagnosis of alcoholic liver disease, apart from
clinical picture and laboratory findings, ultrasonography, transient
elastography, magnetic resonance imaging, serum biomarkers and liver biopsy
are important. Therapy of alcoholic liver disease includes abstinence,
nutritional support, corticosteroid treatment and liver transplantation. New
therapeutic modalities are being investigated. Conclusion. Despite abundant
knowledge of the epidemiology, pathophysiology and clinical diagnostics of
alcoholic liver disease, the therapy has not changed over the past few
decades. The development of novel therapeutic modalities requires a
multidisciplinary approach and close cooperation of doctors and pharmacists.
The emphasis must be put on the disease prevention at both individual and
community level.
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关键词
alcoholic liver disease
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