Meningococcal outer membrane vesicle composition-dependent activation 1 of the innate immune response 2 Running Title : OMVs and innate immunity

Running Title: OMVs and innate immunity 3 Afshin Zariri, Joep Beskers, Bas van de Waterbeemd, Hendrik Jan Hamstra, Tim H.E. 4 Bindels, Elly van Riet, Jos P.M. van Putten, Peter van der Ley 5 6 Institute for Translational Vaccinology (intravacc), Antonie van Leeuwenhoeklaan 9, 3720 7 AL Bilthoven, the Netherlands 8 Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL, Utrecht, 9 the Netherlands 10 3 Immunology of Infectious diseases and Vaccines (IIV), National Institute of Public Health 11 and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 AL Bilthoven, the 12 Netherlands 13 4 Current address: Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN Leiden, 14 the Netherlands 15 16 Corresponding author: 17 Afshin Zariri 18 Institute for Translational Vaccinology (intravacc) 19 Antonie van Leeuwenhoeklaan 9, 3720 AL Bilthoven, the Netherlands 20 Tel: +31302744311 21 Email: Afshin.zariri@intravacc.nl 22 23