Positron emission tomographic imaging in drug discovery

Krishna Kanta Ghosh,Parasuraman Padmanabhan,Chang-Tong Yang,David Chee Eng Ng,Mathangi Palanivel,Sachin Mishra,Christer Halldin,Balázs Gulyás

Drug Discovery Today（2022）

引用 16|浏览8

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摘要

•PET imaging accelerates the selection of drug candidates during the early stages of development.•The estimation of receptor occupancy in the brain is one of the most important applications of PET.•PET is also widely used in pharmacokinetics, biodistribution and treatment monitoring.•There are several applications of PET imaging in oncological and cardiological drug discovery.

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关键词

PET imaging,Drug development,Drug discovery,Receptor occupancy,Biodistribution,Pharmacokinetics,Pharmacodynamics,Drug treatment monitoring,Validation of target engagement

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