Insights into the Importance of WPD-Loop Sequence for Activity and Structure in Protein Tyrosine Phosphatases

Ruidan Shen,Rory M. Crean,Keith J. Olsen,Marina Corbella,Ana Rita Calixto,Teisha Richan,Tiago A. S. Brandão,Ryan D. Berry,Alex Tolman,Patrick Loria,Sean Johnson,Shina Caroline Lynn Kamerlin,Alvan C Hengge

Chemical Science（2022）

引用 9|浏览7

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摘要

Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental...

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关键词

tyrosine,wpd-loop

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