Clinician-Based Performance Status and Its Correlation with Patient-Reported Outcomes: Findings from a Prospective Observational Study in Patients with Mantle Cell Lymphoma

Background: Performance status (PS) is used to estimate patients' general well-being and functional status. It is considered an important factor in clinical treatment decisions and determining eligibility for clinical trials, but there are limited data on how PS assessment by clinicians correlates with what patients are experiencing. We are conducting a prospective observational study (NCT03816683) of patients with mantle cell lymphoma (MCL) who are treated with a novel agent in 42 centers in the United States to track data on toxicities and outcomes. The study includes a patient portal used to prospectively collect information on patient-reported outcomes (PROs). The purpose of this study is to compare Eastern Cooperative Oncology Group (ECOG) PS as determined by clinicians with PROs recorded by patients.