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First in Human Study of an on/Off Switchable CAR-T Cell Platform Targeting CD19 for B Cell Malignancies (CLBR001 + SWI019)

Liana Nikolaenko,Carolyn Mulroney,Peter A. Riedell,Ian W. Flinn,Jose Carlos Cruz,Rakhee Vaidya,Koen van Besien,Michael Emde, Vadim Klyushnichenko, Jonathan Strauss,Eduardo Laborda,Jing Li,Mohit Trikha,Peter G. Schultz,Travis S Young

Blood（2021）

Cited 1|Views13
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Abstract
BACKGROUND: CD19 targeted chimeric antigen receptor (CAR) T cells are a transformative treatment option for patients with relapsed, refractory B cell malignancies. Despite remarkable responses in heavily pretreated patients, challenges remain related to toxicities including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), along with relapse related to tumor antigen loss.
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Key words
cd19,clbr001,cell
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