Stability of lipids in plasma and serum: Effects of temperature-related storage conditions on the human lipidome
Journal of Mass Spectrometry and Advances in the Clinical Lab(2021)
Abstract
•Lipid degradation was induced by storage at typical sample preparation temperatures.•Identification of low abundance lipids that increased several-fold during incubation.•Enzymatic hydrolysis and oxidation were identified as likely causes of degradation.•Most high abundance lipids that degrade do so within method variability.
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Key words
FFA,DAG,TAG,CE,PC,LPC,PE,LPE,SM,CER,PL,LysoPL,HpODE,HpETE,PGD2,15-Hp-PGD2,PLA1,PLA2
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