Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation

Huifang Shi, Yan Qin,Yufeng Tian, Jiaan Wang,Yan Wang,Ziyi Wang,Jie Lv

Immunobiology（2022）

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摘要

•IL-1β specifically induces the accumulation of G-MDSC subset, rather than mo-MDSC subset.•IL-1β controls the activation of Stat3 and Erk1/2.•IL-1β regulated the accumulation of G-MDSCs through Erk1/2 activation.

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关键词

Interleukin-1beta,Granulocytic myeloid-derived suppressor cell,Expansion,Extracellular regulated protein kinase 1/2,Interleukin-6

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