Mcm2 Deficiency Leads to Bone Marrow Failure and Lymphoid Malignancies Dependent on Age and Genetic Background

Toshihiro Matsukawa,Yin Mianmian,Timour Baslan,Yang Jo Chung,Dengchao Cao,Ryan Bertoli,Jack Zhu,Robert L. Walker,Amy Freeland,Erik Knudsen,Paul S. Meltzer,Peter D. Aplan

BLOOD（2021）

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摘要

DNA replicative stress is associated with malignant transformation. Mini-chromosome maintenance 2 (hereafter Mcm2) is a component of the DNA helicase complex that plays a pivotal role in DNA replication. The Mcm2-7 complex is loaded onto chromatin during the G1-phase of the cell cycle and is required for initiation of DNA replication in the subsequent S-phase.

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关键词

bone marrow failure,lymphoid malignancies dependent,bone marrow,deficiency

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