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Anti-CD37 Alpha-Amanitin Conjugated Antibodies As Therapeutic Weapons for Richter's Syndrome

Tiziana Vaisitti,Nicoletta Vitale,Andrea Iannello,Lorenzo Brandimarte,Matilde Micillo,Mauro Giulio Papotti,Arianna Di Napoli,Christian Orlik,Michael Kulke,Andreas Pahl,Silvia Deaglio

BLOOD（2021）

Cited 5|Views9
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Abstract
The leukocyte surface antigen CD37 (TSPAN26), a member of the tetraspanin superfamily, is widely expressed on most malignant B cells, making it an actionable target for treatment of patients with chronic lymphocytic leukemia (CLL) and other B-cell non-Hodgkin lymphoma (NHL) indications. Accordingly, αCD37 antibodies have shown promising results in phase 1/2 clinical trials for CLL and NHL.
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