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A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma

Anagh Anant Sahasrabuddhe,Xiaofei Chen,Kaiyu Ma,Rui Wu,Richa Kapoor,Rishi Raj Chhipa,Xiao Zhang,Ozlem Onder,Joel Wilmore,Brian T. Gaudette,Vinodh Pillai,Marilyn M. Li,Joon-Young Ahn,Fuzon Chung,Philippe Szankasi,Venkatesha Basrur,Kevin P Conlon,Nathanael G. Bailey,Cory M Hogaboam,Robert Rottapel

Blood（2021）

Cited 1|Views23
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Abstract
Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common form of malignant lymphoma and may arise de novo, or through transformation from a pre-existing low-grade B cell lymphoma such as follicular lymphoma (FL). However, the post-translational mechanisms and deregulated pathways underlying the pathogenesis of disease evolution are not fully understood.
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Key words
B-Cell Receptor Signaling,Mantle Cell Lymphoma
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