Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Synthetic Lethality in T-ALL Via Mitochondrial Exhaustion

Natalia Baran,Shraddha Patel,Alessia Lodi,Jose Enriquez Ortiz,Yogesh Dhungana,Meghan Collins,Anna Skwarska,Connie Weng,Cassandra L Ramage,Kala Hayes,Zhihong Zeng,Eric Davis,Gheath Alatrash,Joseph R Marszalek,Jiyang Yu,Pratip K Bhattacharya,Stefano Tiziani,Marina Konopleva

Blood（2021）

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摘要

Metabolic reprogramming is recognized as one of the key hallmarks in acquiring aggressive phenotype and chemoresistance in solid tumors and hematologic malignancies.

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