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Immune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd

Shuichiro Takashima,Roshan Sharma,Anastasiya Egorova,Jason Kuttiyara,Takahiro Ito,Winston Chang,Suze A Jansen,Chen Liu,Caroline Lindemans,Linas Mazutis,Nicolas Robine,Alan M Hanash

Blood（2021）

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Abstract
Crypt apoptosis and regeneration are characteristic findings in GI-GVHD. Intestinal stem cells (ISCs) are critical for maintaining the intestinal epithelium, but their frequencies are reduced in experimental GVHD, and the mechanisms driving crypt regeneration in this context are poorly understood.
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Key words
intestinal stem cells,epithelial regeneration,stem cells,myc expression,immune-mediated,gi-gvhd
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