FOXO1 Dependent Transcription Network Is a Targetable Vulnerability of Mantle Cell Lymphoma

Ja-Young Jang,Inah Hwang,Heng Pan,Michael Kluk,Jun Yao,Xiangao Huang,Maurizio Di Liberto,Zhengming Chen,Karla V Ballman,Lewis C Cantley,Giorgio Inghirami,Olivier Elemento,Robert Baiocchi,Selina Chen-Kiang,Sandro Belvedere,Hongwu Zheng,Jihye Paik

Blood（2021）

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摘要

Mantle cell lymphoma (MCL) often has an adverse prognosis and despite aggressive multimodal treatment with conventional and targeted therapies, the median survival of MCL patients remains approximately 4 years. Thus, there is a significant unmet need to find novel targets and rational combination treatments.

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Lymphomas,Oncology

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