A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Maria Menti-Platten,Janice R Aldrich-Wright,Christopher P Gordon

Organic & Biomolecular Chemistry（2022）

Cited 0|Views13

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Abstract

Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO3-based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl and t-Butyl protecting groups.

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Key words

hydrogenolysis strategy,peptide,flow-based,transition-metal-catalysed,side-chain

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