Impact of the Mediterranean Dietary pattern on n-3 fatty acid tissue levels–A systematic review.

•This is the first systematic review on MedDiet adherence and the impact on tissue n-3 PUFA levels in observational and intervention studies.•Higher adherence to the MedDiet in observational studies demonstrated higher n-3 PUFA.•Most RCT studies demonstrated higher tissue levels of n-3 PUFA.•Inconsistencies and heterogeneity in the description and reporting of all MedDiet interventions was found.•This paper explored dietary sources of n-3 PUFA in MedDiet and these contribute to appreciable changes in tissue levels.