Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review

Jawaher Ansari,Yussra Eltigani Mohmmed,Saad Ghazal-Aswad,Hidayath Ansari,Syed M J Akhter, Omar Hassoun Hadid, Syed Rizwan, Raya Almazrouei,Emad Dawoud,Fathi Azribi,Heba Elhasin, Pawan Kumar, Abdul Rahman Al Sumaida, Khaled Al-Qawasmeh,John Glaholm, M J Hochmair, Syed Hussain,Khalid Balaraj

Gynecologic Oncology Reports（2021）

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摘要

•Metastatic vaginal cancer, rare cancer with limited treatment options.•Pembrolizumab and radiotherapy led to complete response in a patient with metastatic vaginal cancer.•Wall-eyed bilateral internuclear ophthalmoplegia, a new immune related adverse event.

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关键词

Pembrolizumab,Vaginal squamous cell carcinoma,Radiotherapy,Immune related adverse events,Wall-eyed internuclear ophthalmoplegia,Checkpoint inhibitors

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