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The anti-IgE monoclonal antibody omalizumab as adjuvant treatment in desensitization to carboplatin in patients with ovarian cancer

Alessandra Vultaggio, Maria Cristina Petrella, Federica Tomao, Francesca Nencini, Valentina Mecheri, Andrea Marini, Margherita Perlato, Emanuele Vivarelli, Claudia De Angelis, Ilaria Ferrarini, Serena Pillozzi, Andrea Matucci, Lorenzo Antonuzzo

Gynecologic Oncology Reports（2021）

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Abstract
•Ovarian cancer is the most lethal among gynecological cancers.•Carboplatin-based chemotherapy identifies as the main systemic treatment for ovarian cancer patients.•Almost one every three patients treated with carboplatin experiences hypersensitivity reactions.•Patients may experience breakthrough reactions during drug desensitization.•Omalizumab represents a promising new treatment to overcome carboplatin hypersensitivity.
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Key words
Ovarian cancer,Platinum salts,Hypersensitivity reactions,IgE antibiodies,Drug desensitization,Omalizumab
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