Differential regulation of lipopolysaccharide-induced IL-1β and TNF-α production in macrophages by palmitate via modulating TLR4 downstream signaling

Chunyun Fang,Lixia Wang,Jingting Qiao, Lina Chang,Qing He,Xiaona Zhang,Ming Liu

International Immunopharmacology（2022）

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摘要

•PA differentially regulated LPS-induced expression of TNF-α and IL-1β.TLR4 downstream signalling was differentially regulated by PA.•Cellular oxidation of PA was necessary to induce these effects.

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关键词

TLR4,TNF-α,IL-1β,Palmitic acid,Macrophage

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