Antibacterial nanofibers of pullulan/tetracycline-cyclodextrin inclusion complexes for Fast-Disintegrating oral drug delivery

•Pullulan/tetracycline-CD-IC nanofibers were generated via electrospinning.•Hydroxypropyl-β-CD (HPβCD) was used for inclusion complex (IC) formation.•The inclusion complex formation was confirmed by ab initio modelling study.•Pullulan/tetracycline-CD-IC nanofibers disintegrated rapidly in artificial saliva.•Tetracycline-HPβCD-IC provided enhanced release and antibacterial property.