A vibrational in vitro approach to evaluate the potential of monoolein nanoparticles as isofuranodiene carrier in MDA-MB 231 breast cancer cell line: New insights from Infrared and Raman microspectroscopies
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy(2022)
Abstract
•Isofuranodiene is a sesquiterpene with proved multiple anticancer activities.•Cancer cell uptake and availability of isofuranodiene-loaded monoolein is tested.•IR and Raman spectra highlight changes in nucleic acids and carbohydrates.•Spectral changes could be related to apoptosis and nucleic acid fragmentation.
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Key words
Isofuranodiene,Monoolein nanoparticles,MDA-MB 231 cells,Fourier Transform Infrared Microspectroscopy,Raman Microspectroscopy,Chemometrics
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