Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis

Andrea Costamagna,Dora Natalini,Maria Del Pilar Camacho Leal,Matilde Simoni,Luca Gozzelino,Paola Cappello,Francesco Novelli,Chiara Ambrogio,Paola Defilippi,Emilia Turco,Elisa Giovannetti,Emilio Hirsch,Sara Cabodi,Miriam Martini

Gastroenterology（2022）

引用 4|浏览14

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摘要

The adaptor protein p130Cas is an essential player downstream of Kras that boosts the PI3K activity required for acinar metaplasia and subsequent tumor initiation.

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关键词

ADM,Kras,Metaplasia,Carcinogenesis,PDAC

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