Improved GPU Implementations of the Pair-HMM Forward Algorithm for DNA Sequence Alignment

With the rise of Next-Generation Sequencing (NGS) technology, clinical sequencing services become more accessible but are also facing new challenges. The surging demand motivates developments of more efficient algorithms for computational genomics and their hardware acceleration. In this work, we use GPU to accelerate the DNA variant calling and its related alignment problem. The Pair-Hidden Marko...